Staff

Prof. Dr. Masaaki Noji

Dr. Tatsuro Yoneyama

Research project

We are continuing to study the isolation and structure elucidation of novel compounds possessing the biological activities such as antimicrobial, antibacterial, cytotoxic, anti-oxidative activities from edible or inedible mushrooms, crude drugs, medicinal plants or herbs, cymbidium and Cordyceps mushroom. We are also attempting to elucidate the entire molecular mechanism of the biosynthesis of these compounds and to construct a useful substance production system by engineering the biosynthetic system based on the obtained knowledge.

1. Search for biologically active compounds from mushrooms, Cordyceps fungi, and cymbidium.
2. Elucidation of biosynthetic mechanism of useful compounds in medicinal plants
3. Construction of useful compound production system by engineering of biosynthetic system

Publications

1. Pentacyclic triterpenoids, fuscotorunones A and B, with ε-caprolactone in ring E from Fuscoporia torulosa. Noji M, Yoneyama T, Nishihama K, Elshamy AI, Hashimoto T, Umeyama A. Phytochemistry 187 112748 (2021).
2. Phenanthrenes with Potent Antitrypanosomal Activity from Roots of Cymbidium Great Flower ‘Marylaurencin’. Yoneyama T., Iseki K., Baba C., Kitagawa Y., Yoshikawa K., Kawano S., Ishiyama A., Hokari R., Iwatsuki M., Otoguro K., Ōmura S., Hashimoto T., Noji M., Umeyama A. Shouyakugaku zasshi 74 (2) 106-107 (2020).
3. Marylosides A-G, Norcycloartane Glycosides from Leaves of Cymbidium Great Flower ‘Marylaurencin’. Yoneyama T., Iseki K., Noji M., Imagawa H., Hashimoto T., Kawano S., Baba M., Kashiwada Y., Yahagi T., Matsuzaki K., Umeyama A. Molecules, 24, 2504 (1-14) (2019).
4. New alkaloidal metabolites from cultures of entomopathogenic fungus Cordyceps takaomontana NBRC 101754 Hama, Maichi; Elshamy, Abdelsamed I.; Yoneyama, Tatsuro; Kasai, Yusuke; Yamamoto, Hirohumi; Tanigawa, Kana Oshiro, Ayari Noji Masaaki, Ban Sayaka, Imagawa, Hiroshi; Akemi Umeyama Fitoterapia 139, 104364 (2019).
5. Kaemgalangol A: Unusual seco-​isopimarane diterpenoid from aromatic ginger Kaempferia galanga. Swapana, N., Tominaga, T., Suenaga, M., Imagawa, H., Noji, M., Elshamy, A., I., Ibrahim, M., A., A., Hegazy, M., F., Brajakishor, S., C., Umeyama, A. Fitoterapia 129, 47-53 (2018).
6. A New Diphenyl Ether Glycoside from Xylosma longifolium Collected from North-East India. N. Swapana, N., Noji, M., Nishiuma, R., Izumi, M., Imagawa, H., Kasai, Y., Okamoto, Y., Iseki, K., Singh, Ch. B., Asakawa, Y., Umeyama, A., Nat. Prod. Commun., 12, 1273-1275 (2017).
7. Six new lanostane triterpenoids from the fruiting body of Tyromyces sambuceus and antiproliferative activity. Kokudo, N., Okazoe, M., Takahashi, J., Iseki, K., Yoshikawa, K., Imagawa, H., Hashimoto, T., Noji, M., Umeyama, A., Nat. Prod. Commun., 11, 169-172 (2016).
8. Two novel diphenolic metabolites from the inedible mushroom Thelephora palmate. Nishio, A., Mikami, H., Imagawa, H., Hashimoto, T., Tanaka, M., Ito, T., Iguchi, M., Iseki, K., Noji, M., Umeyama, A., Nat. Prod. Commun., 11, 1147-1149 (2016).
9. In vitro antitrypanosomal activity of the secondary metabolites from the mutant strain IU-3 of the insect pathogenic fungus Ophiocordyceps coccidiicola NBRC 100683. Ganaha, M., Yoshii, K., Ōtsuki, Y., Iguchi, M., Okamoto, Y., Iseki, K., Ban, S., Ishiyama, A., Hokari, R., Iwatsuki, M., Otoguro, K., Ōmura, S., Hashimoto, T., Noji, M., Umeyama, A.,Chem. Pharm. Bull., 64, 988–990 (2016).