Staff

Prof. Dr. Toshiyuki Fukada

Dr. Takafumi Hara

Research project

Work in my research group has demonstrated that zinc transporter-mediated zinc signals are indispensible for normal cellular functions, and impairment of zinc signaling causes diseases. “Zinc signaling” is an emerging research field and a novel platform in life sciences, so that I would like to explore the zinc signaling at molecular level, in particular about roles and mechanisms of zinc signaling involved in path-physiological conditions of epithelium, neurological diseases, and cancer. Development of regulators for zinc signaling is also one of my research goals.

Selected recent publications

Original articles

1.Kamimura, D., K. Katsunuma, Y. Arima, T. Atsumi, J.J Jiang, H. Bando, J. Meng, L. Sabharwal, A. Stpfkova, N. Nishikawa, H. Suzuki, H. Ogura, N. Ueda, M. Harada, J. Kobayashi, T. Hasegawa, H. Yoshida, H. Koseki, I. Miura, S. Harada, K. Nishida, H. Kitamura, T. Fukada, T. Hirano, and M. Murakami. mKDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR.

Nature Communications 6, Article number: 7474, 2015

2.Jenkitkasemwong, S., C-Y Wang, R. Coffey, W. Zhang, A. Chan, T. Biel, J-S. Kim, S. Hojyo, T. Fukada, and M. Knutson. SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis.

Cell Metabolism 22: 138–150, 2015

3.Hojyo, S., T. Miyai, H. Fujishiro, M. Kawamura, T. Yasuda, A. Hijikata, BH. Bin, T. Irié, J. Tanaka, T. Atsumi, M. Murakami, M. Nakayama, O. Ohara, S. Himeno, H. Yoshida, H. Koseki, T. Ikawa, K. Mishima, and ※T. Fukada. Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B cell receptor signal strength.

PNAS. 111:11786-91, 2014 (※ corresponding author)

4.Bin BH., S. Hojyo, T. Hosaka, J. Bhin, H. Kano, T. Miyai, M. Ikeda, T. Kimura-Someya Mikako Shirouzu, EG Cho, K. Fukue, T. Kambe, W. Ohashi, KH Kim, J. Seo, DH. Choi, YJ Nam, D. Hwang, A. Fukunaka, Y. Fujitani, S. Yokoyama, A. Superti-Furga, S. Ikegawa, TR Lee, and ※T. Fukada. Molecular pathogenic basis of Spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins.

EMBO Molecular Medicine 6: 1028-1042, 2014 (※ corresponding author)

5.Miyai, T., S. Hojyo, T. Ikawa, M. Kawamura, T. Irié, H. Ogura, A. Hijikata, BH. Bin, T. Yasuda, H. Kitamura, M. Nakayama, O. Ohara, H.o Yoshida, H. Koseki, K. Mishima, and ※T. Fukada. Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development.

Review article

Review article

1.Hojyo S, Miyai T, ※Fukada T.

B-cell receptor strength and zinc signaling: Unraveling the role of zinc transporter ZIP10 in humoral immunity.
Receptor and Clinical Investigation 2: e387; 2015 (※ corresponding author)
2.Bin, BH., S. Hojyo, and ※Fukada T.
Spondylocheirodysplastic Ehlers-Danlos syndrome (SCD-EDS) and the mutant zinc transporter ZIP13.
Rare Diseases 2: e974982; 2014 (※corresponding author)

Book

1.※Fukada, T

Genetic study of zinc transporters and zinc signaling, edited by Collins J
Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals, ELSEVIER (in press) (※corresponding author)
2.※Fukada, T, Hojyo, S., and Bin, B.H.
Zinc signal in growth control and bone diseases, edited by Fukada T, and T. Kambe
Zinc Signals in Cellular Functions and Disorders, Springer, 249-267, 2014 (※corresponding author).