Staff

Prof. Dr. Toshimi Nakamura

Dr. Midori Suenaga

Research project

Elucidation of the causal relationship between diseases and oxidative stress has recently progressed, and the close association of oxidation with the development and progression of not only life-style disorders, but also various intractable diseases and the aging process has been clarified. The ingestionof antioxidative substances is useful for the prevention and treatment of these diseases, and various investigations have been performed. We search for the natural material including the antioxidant material and perform a study to apply it to medical care.
In addition, about pharmaceutical products and nanoparticles used many in the fields of cosmetics, study an absorption course from skin, and the influence on environment.

Publications

1. J Yokota T Kitaoka, K Jobu, D Takuma, A Hamada, M Onogawa, S Yoshioka, S Kyotani, M Miyamura; Eriobotrya japonica seed extract and deep sea water protect against indomethacin-induced gastric mucosal injury in rats. J Nat Med  (2011) 65, 9–17
2. K Muramoto, RD Quan, T Namba, S Kyotani, M Miyamura, Y Nishioka, K Tonosaki, Y L. Doi, H Kaba;  Ameliorative effects of Eriobotrya japonica seed extract on cellular aging in cultured rat fibroblasts . J Nat Med  (2011) 65, 254–261
3. G Sun, Y Liu, J Zhu, M Iguchi, S Yoshioka, M Miyamura and S Kyotani; Immunomodulatory Effect of Eriobotrya japonica Seed Extract on Allergic Dermatitis Rats. J Nutrci Vitaminol  (2010) 56, 145-149
4. S Yoshioka, A Hamada, K Jobu, J Yokota, M Onogawa, S Kyotani, M Miyamura,T Saibara, S Onishi and Y Nishioka; Effects of Eriobotrya japonica seed extract on oxidative stress in rats with non-alcoholic steatohepatitis. Journal of Pharmacy and Pharmacology (2010) 62, 241–246
5. M Onogawaa, G Sun, D Takuma, A Hamada, J Yokota, S Yoshioka, M Kusunose, MiMiyamura, S Kyotani and Y Nishioka; Animal studies supporting the inhibition of mast cell activation by Eriobotrya japonica seed extract. Journal of Pharmacy and Pharmacology (2009) 61, 237–241
6. J Yokota ,D Takuma ,A Hamada, M Onogawa , Saburo Yoshioka  Masahiko Kusunose,  Mitsuhiko Miyamura, Shojiro Kyotani, Yutaka Nishioka; Gastroprotective activity of Eriobotrya japonica seed extract on experimentally induced gastric lesions in rats. J Nat Med  (2008) 62, 96–100
7. Daisuke Takuma, Sun Guangchen, Junko Yokota, Atsuhide Hamada, Masahide Onogawa, Saburo Yoshioka, Masahiko Kunose, Mitsuhiko Miyamura, Shojiro Kyotani, and Yutaka Nishioka; Effect of Eriobotrya japonica Seed Extract on 5-Fluorouracil-Induced Mucositis in Hamsters . Biol Pharm Bull (2008) 31, 250-254
8. Yutaka Nishioka, Taisuke Kitaoka, Atsuhide Hamada, Masahide Onogawa,Junko Yokota Taisuke Kitaoka, Kohei Jobu, Daisuke Takuma, Masahide Onogawa, Saburo Yoshioka, Mitsuhiko Miyamura Shojiro Kyotani, et.al ; A Clinical Study of Eriobotrya japonica Seed Extract for the Japanese Cedar Pollinosis. Jpn Pharmacol Ther (2008) 36, 359-364
9. Guangchen Sun, Yixiu Zhang, Daisuke Takuma, Masahide Onogawa, Junko Yokota, Atsuhide Hamada, Saburo Yoshioka, Masahiko Kusunose,Mitsuhiko Miyamura, Shojiro Kyotani and Yutaka Nishioka; Effect of orally administered Eriobotrya japonica seed extract on allergic contact dermatitis in rats. Journal of Pharmacy and Pharmacology  (2007) 59, 1405–1412
10. Junko Yokota, Daisuke Takuma, Atsuhide Hamada, Masahide Onogawa, Saburo Yoshioka, Masahiko Kusunose, Mitsuhiko Miyamura, Shojiro Kyotani, and Yutaka Nishioka; Scavenging of Reactive Oxygen Species by Eriobotrya japonica Seed Extract. Biol Pharm Bull (2006) 29, 467—471